The lissencephaly-related protein LIS1 is a critical regulator of cytoplasmic dynein that
governs motor function and intracellular localization (for example, to microtubule plus-ends). …

Thousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic ciliary
beat. Coordination among multiple OADs is essential for generating mechanical forces to …

Group II introns are ribozymes that catalyze their self-excision and function as retroelements
that invade DNA. As retrotransposons, group II introns form ribonucleoprotein (RNP) …

Accurately regulated ciliary beating in time and space is critical for diverse cellular activities,
which impact the survival and development of nearly all eukaryotic species. An essential …

Abl family kinases are evolutionarily conserved regulators of cell migration and morphogenesis.
Genetic experiments in Drosophila suggest that Abl family kinases interact functionally …

Radial spokes (RS) are T-shaped multiprotein complexes on the axonemal microtubules.
Repeated RS1, RS2, and RS3 couple the central pair to modulate ciliary and flagellar motility. …

Revealing high-resolution structures of microtubule-associated proteins (MAPs) is critical for
understanding their fundamental roles in various cellular activities, such as cell motility and …

The lissencephaly-related protein LIS1 is a critical regulator of cytoplasmic dynein that
governs motor function and intracellular localization (e.g., to microtubule plus-ends). Although …

Radial spokes (RSs) are T-shaped multiprotein complexes in the 9+2 axoneme of motile cilia
and flagella that couple the central pair to the peripheral doublet microtubules. RS1, RS2, …

Thousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic
ciliary beat. Using electron microscopy, we determined the structure of OAD array bound to …