Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

The 3β-hydroxysteroid dehydrogenase/Δ 5 -Δ 4 isomerase (3β-HSD) isoenzymes are
responsible for the oxidation and isomerization of Δ 5 -3β-hydroxysteroid precursors into Δ 4 -…

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this
risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 …

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC),
we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC …

Background: Common cancers develop through a multistep process often including inherited
susceptibility. Collaboration among multiple institutions, and funding from multiple sources, …

Most common breast cancer susceptibility variants have been identified through genome-wide
association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease 1 . …

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic
variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of …

Background Genome-wide association studies (GWAS) have identified 94 common single-nucleotide
polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated …

Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC)
susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and …

17β-Hydroxysteroid dehydrogenases (17βHSDs) play an essential role in the formation of
active intracellular sex steroids. Six types of 17βHSD have been described to date, which only …