Despite the promise of RNA interference (RNAi) and its potential, eg for use in cancer
therapy, several technical obstacles must first be overcome. The major hurdle of RNAi-based …

During the last decade, the vast omics field has revolutionized biological research, especially
the genomics, transcriptomics and proteomics branches, as technological tools become …

RNA-based therapeutics hold great promise for treating diseases and lipid nanoparticles (LNPs)
represent the most advanced platform for RNA delivery. However, the fate of the LNP-…

The RNA that is packaged into exosomes is termed as exosomal-shuttle RNA (esRNA);
however, the players, which take this subset of RNA (esRNA) into exosomes, remain largely …

We demonstrate a role in oxidative and metal stress resistance for the MAPK‐activated
protein kinases Rck1 and Rck2 in Saccharomyces cerevisiae. We show that Hog1 is robustly …

Hus1 is one of six checkpoint Rad proteins required for allSchizosaccharomyces pombe DNA
integrity checkpoints. MYC-tagged Hus1 reveals four discrete forms. The main form, Hus1-…

… YPD medium contains, per 1 liter, 10 g of yeast … ) per liter, 5 g of (NH 4 ) 2 SO 4 per liter,
20 g of dextrose per liter, and supplements (100 mg each of amino acids, uracil, or adenine per …

The number of chromosome sets contained within the nucleus of eukaryotic organisms is a
fundamental yet evolutionarily poorly characterized genetic variable of life. Here, we mapped …

To remain competitive, cells exposed to stress of varying duration, rapidity of onset, and
intensity, have to balance their expenditure on growth and proliferation versus stress protection. …

Under stress, cells need to optimize the activity of a wide range of gene products during the
response phases: shock, adaptation, and recovery. This requires coordination of several …