A pre-requisite to understanding the physiological mechanisms of action of melatonin is the
identification of the target sites where the hormone acts. The radioligand 2-[ 125 I]…

Mel 1a melatonin receptors belong to the superfamily of guanine nucleotide-binding regulatory
protein (G protein)-coupled receptors. So far, interest in Mel 1a receptor signaling has …

Seasonal adaptations in physiology exhibited by many animals involve an interface between
biological timing and specific neuroendocrine systems, but the molecular basis of this …

Seasonal mammals typically of temperate or boreal habitats use the predictable annual cycle
of daylength to initiate a suite of physiological and behavioural changes in anticipation of …

The rhythm of life on earth is shaped by seasonal changes in the environment. Plants and
animals show profound annual cycles in physiology, health, morphology, behaviour and …

The melatonin receptor family is a small group of receptors within the G protein‐coupled
receptor (GPCR) superfamily. The group comprises of three subtypes which bind melatonin and …

The mammalian Per1 gene is expressed in the suprachiasmatic nucleus of the hypothalamus,
where it is thought to play a critical role in the generation of circadian rhythms. Per1 …

Seasonal rhythms of body weight, reflecting altered food intake, energy storage and expenditure,
are a common feature of mammals inhabiting temperate and arctic latitudes. They have …

Endothermic mammals and birds require intensive energy turnover to sustain high body
temperatures and metabolic rates. To cope with the energetic bottlenecks associated with the …

Siberian hamsters display photoperiodically regulated annual cycles in body weight, appetite,
and reproduction. Previous studies have revealed a profound up-regulation of type 3 …