User profiles for Perumal Arumugam Desingu
 | Perumal Arumugam DesinguINSPIRE Faculty, Department of Microbiology and Cell Biology, Indian Institute of Science … Verified email at iisc.ac.in Cited by 1683 |
Emergence of SARS-CoV-2 Omicron (B. 1.1. 529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic
Since the appearance in the late of December 2019, SARS-CoV-2 is rapidly evolving and
mutating continuously, giving rise to various variants with variable degrees of infectivity and …
mutating continuously, giving rise to various variants with variable degrees of infectivity and …
Ebola virus–epidemiology, diagnosis, and control: threat to humans, lessons learnt, and preparedness plans–an update on its 40 year's journey
…, M Saminathan, S Sachan, PA Desingu… - Veterinary …, 2017 - Taylor & Francis
Ebola virus (EBOV) is an extremely contagious pathogen and causes lethal hemorrhagic fever
disease in man and animals. The recently occurred Ebola virus disease (EVD) outbreaks …
disease in man and animals. The recently occurred Ebola virus disease (EVD) outbreaks …
[HTML][HTML] Subcutaneous Ehrlich Ascites Carcinoma mice model for studying cancer-induced cardiomyopathy
Cardiomyopathy is one of the characteristic features of cancer. In this study, we establish a
suitable model to study breast cancer-induced cardiomyopathy in mice. We used Ehrlich …
suitable model to study breast cancer-induced cardiomyopathy in mice. We used Ehrlich …
[HTML][HTML] Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice
Caloric restriction has been associated with increased life span and reduced aging-related
disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of …
disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of …
Need of booster vaccine doses to counteract the emergence of SARS-CoV-2 variants in the context of the Omicron variant and increasing COVID-19 cases: An update
The emergence of different variants of SARS-CoV-2, including the Omicron (B.1.1.529) variant
in November 2021, has resulted in a continuous major health concern at a global scale. …
in November 2021, has resulted in a continuous major health concern at a global scale. …
[HTML][HTML] Evolution of monkeypox virus from 2017 to 2022: In the light of point mutations
PA Desingu, TP Rubeni, NR Sundaresan - Frontiers in microbiology, 2022 - frontiersin.org
Monkeypox virus (MPXV) causing multi-country outbreak-2022 is related to viruses caused
outbreak-2017–2018 in West Africa. Still not fully understood which proteins of the MPXV …
outbreak-2017–2018 in West Africa. Still not fully understood which proteins of the MPXV …
SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH2-terminal kinase
c-Jun NH 2 -terminal kinases (JNKs) are responsive to stress stimuli and their activation
regulate key cellular functions, including cell survival, growth, differentiation and aging. Previous …
regulate key cellular functions, including cell survival, growth, differentiation and aging. Previous …
[HTML][HTML] Systematic evaluation of the adaptability of the non-radioactive SUnSET assay to measure cardiac protein synthesis
Heart is a dynamic organ that undergoes remodeling in response to both physiological and
pathological stimuli. One of the fundamental cellular processes that facilitates changes in the …
pathological stimuli. One of the fundamental cellular processes that facilitates changes in the …
[HTML][HTML] Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice
Toll-like receptors (TLRs) are a family of pattern-recognition receptors involved in innate
immunity. Previous studies have shown that TLR2 inhibition protects the heart from acute stress, …
immunity. Previous studies have shown that TLR2 inhibition protects the heart from acute stress, …
SARS-CoV-2 gained a novel spike protein S1–N-Terminal Domain (S1-NTD)
The clue behind the SARS-CoV-2 origin is still a matter of debate. Here, we report that SARS-CoV-2
has gained a novel spike protein S1–N-terminal domain (S1-NTD). In our CLuster …
has gained a novel spike protein S1–N-terminal domain (S1-NTD). In our CLuster …