The PTPN11 gene encodes SHP-2 (Src homology 2 domain–containing protein tyrosine
Phosphatase), a nonreceptor tyrosine protein tyrosine phosphatase (PTPase) that relays …

Germline mutations in PTPN11, the gene encoding the protein tyrosine phosphatase SHP-2,
cause Noonan syndrome (NS) and the clinically related LEOPARD syndrome (LS), …

Juvenile chronic myelogenous leukemia (JCML) is a good model for the study of myeloproliferation
because JCML hematopoietic progenitor cells grow in vitro at very low cell densities …

Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder characterized
by malignant transformation in the hematopoietic stem cell compartment with proliferation …

Germ line PTPN11 mutations cause 50% of cases of Noonan syndrome (NS). Somatic
mutations in PTPN11 occur in 35% of patients with de novo, nonsyndromic juvenile …

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of
childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% …

Juvenile myelomonocytic leukemia (JMML) is a pediatric myelodysplastic syndrome that is
associated with neurofibromatosis, type 1 (NF1). The NF1 tumor suppressor gene encodes …

The possibility that umbilical cord and placental blood from an HLA- identical sibling might
produce stable donor-derived lymphohematopoietic engraftment was tested in a patient with …

Immunopurified TFIID produces a large DNase I footprint over the hsp70, hsp26, and histone
H3 promoters of Drosophila. These footprints span from the TATA element to a position …

The type I insulin-like growth factor receptor (IGF-IR) is an integral component in the control
of cell proliferation, differentiation and apoptosis. The IGF-IR mRNA contains an …