A fundamental biological question is what forces shape the guanine plus cytosine (GC) content
of genomes. We studied the specificity and rate of different mutational biases in real time …

Background During general anaesthesia for noncardiac surgery, there remain knowledge
gaps regarding the effect of goal-directed haemodynamic therapy on patient-centred outcomes…

10.7554/eLife.07074.001 Replicate populations of natural and experimental organisms
often show evidence of parallel genetic evolution, but the causes are unclear. The wrinkly …

Objectives To provide an updated systematic review on the use of extracorporeal
cardiopulmonary resuscitation (ECPR) compared with manual or mechanical cardiopulmonary …

The distribution of fitness effects (DFE) of mutations is of fundamental importance for understanding
evolutionary dynamics and complex diseases and for conserving threatened species…

Genes introduced by gene replacements and other types of horizontal gene transfer (HGT)
represent a significant presence in many archaeal and eubacterial genomes. Most alien …

Aim To perform a systematic review of the literature on intravenous (IV) vs. intraosseous (IO)
administration of drugs during cardiac arrest in order to inform an update of international …

10.7554/eLife.38822.001 Predicting evolutionary change poses numerous challenges.
Here we take advantage of the model bacterium Pseudomonas fluorescens in which the …

In semi‐arid climates, seasonally‐flowing streams provide most of the water required for
human use, but knowledge of how water extraction affects ecological processes is limited. …

Over the last two decades interest in direct realisation of evolutionary process and the
possibilities presented by real time evolution experiments with microbes have escalated. Long-…