Histidine protein kinases (HPKs) are a large family of signal-transduction enzymes that
autophosphorylate on a conserved histidine residue. HPKs form two-component signaling …

INTRODUCTION Cells migrate over long distances during normal embryonic development
and in disease, and they navigate through complex, branched paths. Chemotaxis, cell …

Nutrient-deprived Dictyostelium amoebae aggregate to form a multicellular structure by
chemotaxis, moving towards propagating waves of cyclic AMP that are relayed from cell to cell. …

Terminal differentiation of both stalk and spore cells in Dictyostelium can be triggered by
activation of cAMP-dependent protein kinase (PKA). A screen for mutants where stalk and spore …

Actin-based protrusions are reinforced through positive feedback, but it is unclear what restricts
their size, or limits positive signals when they retract or split. We identify an evolutionarily …

Dictyostelium has a mature technology for molecular-genetic manipulation based around
transfection using several different selectable markers, marker re-cycling, homologous …

Actin pseudopods induced by SCAR/WAVE drive normal migration and chemotaxis in
eukaryotic cells. Cells can also migrate using blebs, in which the edge is driven forward by …

WASH causes actin to polymerize on vesicles involved in retrograde traffic and exocytosis. It
is found within a regulatory complex, but the physiological roles of the other four members …

Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA) gradients.
The cells break down LPA, which is present at high levels around the tumours, creating …

The regA and rdeA gene products of Dictyostelium are involved in the regulation of cAMP
signaling. The response regulator, RegA, is composed of an N-terminal receiver domain linked …