Rhinoviruses are the major trigger of acute asthma exacerbations and asthmatic subjects
are more susceptible to these infections. To investigate the underlying mechanisms of this …

Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased
susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient …

Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death
globally, and manifests as a progressive inflammatory lung disease with no curative treatment. …

Patients with asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS) have
been largely excluded from pivotal therapeutic trials and, as a result, its treatment remains …

Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy.
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …

BACKGROUND: Cigarette smoke–induced chronic obstructive pulmonary disease (COPD)
is a life-threatening inflammatory disorder of the lung. The development of effective therapies …

BACKGROUND: Rhinovirus-induced acute asthma is the most frequent trigger for asthma
exacerbations. OBJECTIVE: We assessed which inflammatory mediators were released from …

“Treatable traits” have been proposed as a new paradigm for the management of airway
diseases, particularly complex disease, which aims to apply personalised medicine to each …

Background Inflammation is associated with an increased risk of a range of chronic diseases.
A diet high in fruit and vegetables may help to reduce inflammation, as fruit and vegetables …

Rationale: Necroptosis, mediated by RIPK3 (receptor-interacting protein kinase 3) and MLKL
(mixed lineage kinase domain-like), is a form of regulated necrosis that can drive tissue …