The human transcriptome comprises >80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million. …

Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

There is an urgent need to improve the infrastructure supporting the reuse of scholarly data.
A diverse set of stakeholders—representing academia, industry, funding agencies, and …

Genome sequencing projects are discovering millions of genetic variants in humans, and
interpretation of their functional effects is essential for understanding the genetic basis of …

Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …

The FANTOM5 project investigates transcription initiation activities in more than 1,000 human
and mouse primary cells, cell lines and tissues using CAGE. Based on manual curation of …

The hippocampal expression profiles of wild-type mice and mice transgenic for δC-doublecortin-like
kinase were compared with Solexa/Illumina deep sequencing technology and five …

Cells release RNA-carrying vesicles and membrane-free RNA/protein complexes into the
extracellular milieu. Horizontal vesicle-mediated transfer of such shuttle RNA between cells …

Advances in omics technologies allow for holistic studies into biological systems. These
studies rely on integrative data analysis techniques to obtain a comprehensive view of the …

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …