Differentiation is a means by which unicellular parasites adapt to different environments. In
some cases, the developmental program may be modulated by interactions with the host, but …

Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and
sphingolipid classes. These are de novo synthesized from precursors obtained either from the …

Many cell surface proteins are attached to membranes via covalent glycosylphosphatidylinositol
(GPI) anchors that are posttranslationally linked to the carboxy‐terminus of the protein. …

Phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are among the most abundant
phospholipids in biological membranes. In many eukaryotes, the CDP-ethanolamine and …

Phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are the two major
constituents of eukaryotic cell membranes. In the protist Trypanosoma brucei, PE and PC are …

We present a quantitative description of the molecular species composition of the major
phospholipid classes in bloodstream and procyclic forms of Trypanosoma brucei. Phospholipid …

Cardiolipin is important for bacterial and mitochondrial stability and function. The final step
in cardiolipin biosynthesis is catalyzed by cardiolipin synthase and differs mechanistically …

Phosphatidylethanolamine is a major phospholipid class of all eukaryotic cells. It can be
synthesized via the CDP-ethanolamine branch of the Kennedy pathway, by decarboxylation of …

Procyclic forms of Trypanosoma brucei reside in the midgut of tsetse flies where they are
covered by several million copies of glycosylphosphatidylinositol-anchored proteins known as …

The surface of Trypanosoma brucei brucei insect forms is covered by an invariant protein
coat consisting of procyclins. There are six or seven procyclin genes that encode unusual …