User profiles for Peter B. Stathopulos
Peter StathopulosAssistant Professor of Physiology and Pharmacology, Western University Verified email at schulich.uwo.ca Cited by 19773 |
[HTML][HTML] Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry
Stromal interaction molecule-1 (STIM1) activates store-operated Ca 2+ entry (SOCE) in
response to diminished luminal Ca 2+ levels. Here, we present the atomic structure of the Ca 2+ -…
response to diminished luminal Ca 2+ levels. Here, we present the atomic structure of the Ca 2+ -…
[HTML][HTML] Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region
PB Stathopulos, GY Li, MJ Plevin, JB Ames… - Journal of Biological …, 2006 - ASBMB
Stromal interaction molecule 1 (STIM1) has recently been identified as a key player in store-operated
Ca 2+ entry. Endoplasmic reticulum (ER) luminal Ca 2+ depletion results in STIM1 …
Ca 2+ entry. Endoplasmic reticulum (ER) luminal Ca 2+ depletion results in STIM1 …
Sonication of proteins causes formation of aggregates that resemble amyloid
PB Stathopulos, GA Scholz, YM Hwang… - Protein …, 2004 - Wiley Online Library
Despite the widespread use of sonication in medicine, industry, and research, the effects of
sonication on proteins remain poorly characterized. We report that sonication of a range of …
sonication on proteins remain poorly characterized. We report that sonication of a range of …
[HTML][HTML] STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry
Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1
(STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium …
(STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium …
Initial activation of STIM1, the regulator of store-operated calcium entry
…, P Meraner, A Gudlur, PB Stathopulos… - Nature structural & …, 2013 - nature.com
Physiological Ca 2+ signaling in T lymphocytes and other cells depends on the STIM-ORAI
pathway of store-operated Ca 2+ entry. STIM1 and STIM2 are Ca 2+ sensors in the …
pathway of store-operated Ca 2+ entry. STIM1 and STIM2 are Ca 2+ sensors in the …
[PDF][PDF] Mitochondrial Ca2+ uniporter is a mitochondrial luminal redox sensor that augments MCU channel activity
Ca 2+ dynamics and oxidative signaling are fundamental mechanisms for mitochondrial
bioenergetics and cell function. The MCU complex is the major pathway by which these signals …
bioenergetics and cell function. The MCU complex is the major pathway by which these signals …
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
…, PB Stathopulos… - Proceedings of the …, 2015 - National Acad Sciences
K-RAS4B (Kirsten rat sarcoma viral oncogene homolog 4B) is a prenylated, membrane-associated
GTPase protein that is a critical switch for the propagation of growth factor signaling …
GTPase protein that is a critical switch for the propagation of growth factor signaling …
[HTML][HTML] Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics
PB Stathopulos, L Zheng, M Ikura - Journal of biological chemistry, 2009 - ASBMB
Stromal interaction molecules (STIM) 1 and STIM2 are regulators of store-operated calcium (Ca
2+ ) entry as well as basal cytoplasmic Ca 2+ levels in human cells. Despite a high …
2+ ) entry as well as basal cytoplasmic Ca 2+ levels in human cells. Despite a high …
Structural and functional conservation of key domains in InsP3 and ryanodine receptors
MD Seo, S Velamakanni, N Ishiyama, PB Stathopulos… - Nature, 2012 - nature.com
Inositol-1,4,5-trisphosphate receptors (InsP 3 Rs) and ryanodine receptors (RyRs) are
tetrameric intracellular Ca 2+ channels 1 . In each of these receptor families, the pore, which is …
tetrameric intracellular Ca 2+ channels 1 . In each of these receptor families, the pore, which is …
Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2
L Zheng, PB Stathopulos, GY Li, M Ikura - Biochemical and biophysical …, 2008 - Elsevier
Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum (ER)-membrane
associated Ca 2+ sensor which activates store-operated Ca 2+ entry (SOCE). Its homologue, …
associated Ca 2+ sensor which activates store-operated Ca 2+ entry (SOCE). Its homologue, …