The cytoplasmic Ca2+ concentration ([Ca2+]i) was measured in single pancreatic mouse
islets superfused in a system allowing concomitant recordings of insulin release. When …

Context: Proglucagon-derived hormones are important for glucose metabolism, but little is
known about them in pediatric obesity and type 2 diabetes mellitus (T2DM). Objective: Fasting …

Background The incidence of type 1 diabetes (T1D) is increasing globally. One hypothesis is
that increasing childhood obesity rates may explain part of this increase, but, as T1D is rare…

Palmitate negatively affects insulin secretion and apoptosis in the pancreatic β‐cell. The
detrimental effects are abolished by elongating and desaturating the fatty acid into oleate. To …

Fatty acids affect insulin secretion via metabolism and FFAR1-mediated signaling. Recent
reports indicate that these two pathways act synergistically. Still it remains unclear how they …

Completion of the human genome sequence has provided scientists with powerful resources
with which to explore the molecular events associated with disease states such as diabetes…

Ascorbic acid (vitamin C) was found in isolated human mononuclear leukocytes and their
purified components in millimolar concentration. Intracellular ascorbic acid was depleted …

The insulin secretory response to glucose was studied in single pancreatic islets isolated
from ob/ob mice and rats. The perfusate from an individual islet was collected during 18-s …

Free fatty acids (FFAs) have pleiotropic effects on the pancreatic β-cell. Although acute
exposure to FFAs stimulates glucose-stimulated insulin secretion (GSIS), prolonged exposure …

Cytoplasmic Ca2+ concentration ([Ca2+]i) and insulin secretion were monitored in single ob/ob
mouse pancreatic islets stimulated by glucose. After culture in 5.5 mM of the sugar, islets …