User profiles for Peter Broderick
Peter BroderickInstitute of Cancer Research Verified email at icr.ac.uk Cited by 16606 |
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25. 1
To identify risk variants for lung cancer, we conducted a multistage genome-wide association
study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and …
study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and …
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
…, KM Howarth, E Domingo, AM Jones, P Broderick… - Nature …, 2013 - nature.com
Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer
(CRC) have no detectable germline mutations in the known cancer predisposition genes. …
(CRC) have no detectable germline mutations in the known cancer predisposition genes. …
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24. 21
Much of the variation in inherited risk of colorectal cancer (CRC) is probably due to
combinations of common low risk variants. We conducted a genome-wide association study of …
combinations of common low risk variants. We conducted a genome-wide association study of …
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
In a genome-wide association study to identify loci associated with colorectal cancer (CRC)
risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 …
risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 …
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23. 3
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide
association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor …
association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor …
Common 5p15. 33 and 6p21. 33 variants influence lung cancer risk
We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919
SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was …
SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was …
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association
study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 …
study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 …
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
MC Di Bernardo, D Crowther-Swanepoel, P Broderick… - Nature …, 2008 - nature.com
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic
leukemia (CLL) and performed validation in two additional series totaling 1,529 cases …
leukemia (CLL) and performed validation in two additional series totaling 1,529 cases …
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) …
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) …
[HTML][HTML] Multiple independent loci at chromosome 15q25. 1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD
…, AS Wenzlaff, SH Aggen, N Breslau, P Broderick… - PLoS …, 2010 - journals.plos.org
Recently, genetic association findings for nicotine dependence, smoking behavior, and
smoking-related diseases converged to implicate the chromosome 15q25.1 region, which …
smoking-related diseases converged to implicate the chromosome 15q25.1 region, which …