User profiles for Peter Broderick

Peter Broderick

Institute of Cancer Research
Verified email at icr.ac.uk
Cited by 16606

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25. 1

CI Amos, X Wu, P Broderick, IP Gorlov, J Gu, T Eisen… - Nature …, 2008 - nature.com
To identify risk variants for lung cancer, we conducted a multistage genome-wide association
study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and …

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

…, KM Howarth, E Domingo, AM Jones, P Broderick… - Nature …, 2013 - nature.com
Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer
(CRC) have no detectable germline mutations in the known cancer predisposition genes. …

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24. 21

…, E Webb, L Carvajal-Carmona, P Broderick… - Nature …, 2007 - nature.com
Much of the variation in inherited risk of colorectal cancer (CRC) is probably due to
combinations of common low risk variants. We conducted a genome-wide association study of …

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

…, L Carvajal-Carmona, E Webb, P Broderick… - Nature …, 2008 - nature.com
In a genome-wide association study to identify loci associated with colorectal cancer (CRC)
risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 …

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23. 3

…, E Webb, L Carvajal-Carmona, P Broderick… - Nature …, 2008 - nature.com
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide
association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor …

Common 5p15. 33 and 6p21. 33 variants influence lung cancer risk

Y Wang, P Broderick, E Webb, X Wu, J Vijayakrishnan… - Nature …, 2008 - nature.com
We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919
SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was …

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

P Broderick, L Carvajal-Carmona, AM Pittman… - Nature …, 2007 - nature.com
To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association
study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 …

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

MC Di Bernardo, D Crowther-Swanepoel, P Broderick… - Nature …, 2008 - nature.com
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic
leukemia (CLL) and performed validation in two additional series totaling 1,529 cases …

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

…, T Rafnar, Z Wang, MN Timofeeva, P Broderick… - Nature …, 2014 - nature.com
We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) …

[HTML][HTML] Multiple independent loci at chromosome 15q25. 1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD

…, AS Wenzlaff, SH Aggen, N Breslau, P Broderick… - PLoS …, 2010 - journals.plos.org
Recently, genetic association findings for nicotine dependence, smoking behavior, and
smoking-related diseases converged to implicate the chromosome 15q25.1 region, which …