Curli amyloid fibers are the major protein component of the extracellular matrix produced by
Enterobacteriaceae during biofilm formation. Curli are required for proper biofilm …

All organisms regulate cell cycle progression by coordinating cell division with DNA replication
status. In eukaryotes, DNA damage or problems with replication fork progression induce …

Bacterial MutS proteins are subdivided into two families, MutS1 and MutS2. MutS1 family
members recognize DNA replication errors during their participation in the well-characterized …

Transcriptional regulation by Wnt signalling is primarily thought to be accomplished by a
complex of β-catenin and TCF family transcription factors (TFs). Although numerous studies …

Activation of the Wnt/β-catenin pathway regulates gene expression by promoting the formation
of a β-catenin–T-cell factor (TCF) complex on target enhancers. In addition to TCFs, other …

A fundamental procedure for most modern biologists is the genetic manipulation of the organism
under study. Although many different methods for editing bacterial genomes have been …

The Wnt/β-catenin signaling pathway plays many important roles in animal development,
tissue homeostasis and human disease. Transcription factors of the TCF family mediate many …

All organisms possess DNA repair pathways that are used to maintain the integrity of their
genetic material. Although many DNA repair pathways are well understood, new pathways …

During normal DNA replication, all cells encounter damage to their genetic material. As a
result, organisms have developed response pathways that provide time for the cell to complete …

Few discoveries have been more transformative to the biological sciences than the
development of DNA sequencing technologies. The rapid advancement of sequencing and …