The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important
determinant of adaptive immunity. We estimated the abundance of TCR sequences in …

CD8 + T cells play an important role in protection against viral infections. With age, changes
in the T-cell pool occur, leading to diminished responses against both new and recurring …

T cells recognize pathogens by their highly specific T-cell receptor (TCR), which can bind
small fragments of an antigen presented on the Major Histocompatibility Complex (MHC). …

T cells play an important role in adaptive immunity. An enormous clonal diversity of T cells
with a different specificity, encoded by the T cell receptor (TCR), protect the body against …

T-cell receptor (TCR) repertoire sequencing data provides quantitative insight into the distribution
of T-cell clones. The diversity of the TCR repertoire in humans tends do decrease with …

In this practical we work with an ‘artificial immune system’composed of a large set of random
detectors (as a model for lymphocyte receptors) that are defined as random strings of letters …

Purpose The treatment of acute myeloid leukemia (AML) in first relapse is associated with
unsatisfactory rates of complete responses that usually are short lived. Therefore, a clinically …

Purpose Half the patients with acute myeloid leukemia (AML) who achieve complete
remission (CR), ultimately relapse. Residual treatment-surviving leukemia is considered …

Autosomal-recessive immunodeficiency, centromeric instability, and facial anomalies (ICF)
syndrome is mainly characterized by recurrent, often fatal, respiratory and gastrointestinal …

Pathogen reduction (PR) of platelet products increases costs and available clinical studies
are equivocal with respect to clinical and haemostatic effectiveness. We conducted a …