User profiles for Peter Campbell

Peter Campbell

Wellcome Sanger Institute
Verified email at sanger.ac.uk
Cited by 133883

Signatures of mutational processes in human cancer

…, E Campo, T Shibata, SM Pfister, PJ Campbell… - Nature, 2013 - nature.com
All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Patterns of somatic mutation in human cancer genomes

…, A DeFazio, MF Greaves, AR Green, P Campbell… - Nature, 2007 - nature.com
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing of …

[HTML][HTML] Massive genomic rearrangement acquired in a single catastrophic event during cancer development

…, AM Flanagan, MR Stratton, PA Futreal, PJ Campbell - cell, 2011 - cell.com
Cancer is driven by somatically acquired point mutations and chromosomal rearrangements,
conventionally thought to accumulate gradually over time. Using next-generation …

Origins and functional impact of copy number variation in the human genome

…, Y Zhang, J Aerts, TD Andrews, C Barnes, P Campbell… - Nature, 2010 - nature.com
Structural variations of DNA greater than 1 kilobase in size account for most bases that vary
among human genomes, but are still relatively under-ascertained. Here we use tiling …

[HTML][HTML] A comprehensive catalogue of somatic mutations from a human cancer genome

…, D Williamson, L Chin, MT Ross, PJ Campbell… - Nature, 2010 - nature.com
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver
mutations, confer selective growth advantage and are implicated in cancer development, …

Somatic mutation in cancer and normal cells

I Martincorena, PJ Campbell - Science, 2015 - science.org
Spontaneously occurring mutations accumulate in somatic cells throughout a person’s lifetime.
The majority of these mutations do not have a noticeable effect, but some can alter key …

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

…, NT Ueno, C Sotiriou, A Viari, PA Futreal, PJ Campbell… - Nature, 2016 - nature.com
We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

High burden and pervasive positive selection of somatic mutations in normal human skin

…, S Widaa, MR Stratton, PH Jones, PJ Campbell - Science, 2015 - science.org
How somatic mutations accumulate in normal cells is central to understanding cancer
development but is poorly understood. We performed ultradeep sequencing of 74 cancer genes in …

COSMIC: the catalogue of somatic mutations in cancer

…, S Wang, S Ward, PJ Campbell… - Nucleic acids …, 2019 - academic.oup.com
COSMIC, the Catalogue Of Somatic Mutations In Cancer ( https://cancer.sanger.ac.uk ) is the
most detailed and comprehensive resource for exploring the effect of somatic mutations in …

[PDF][PDF] Universal patterns of selection in cancer and somatic tissues

…, P Van Loo, H Davies, MR Stratton, PJ Campbell - Cell, 2017 - cell.com
Cancer develops as a result of somatic mutation and clonal selection, but quantitative
measures of selection in cancer evolution are lacking. We adapted methods from molecular …