Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and
silencing 1 , 2 , 3 . However, we recently discovered the presence of cytoplasmic chromatin …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking
process that degrades a variety of cellular constituents and is associated with human diseases …

SIRT1 (Sir2) is an NAD + -dependent deacetylase that plays critical roles in a broad range of
biological events, including metabolism, the immune response and ageing 1 , 2 , 3 , 4 – 5 . …

E2F-1 is a transcription factor suspected of activating genes required for S phase and a
known target for the action of RB, the retinoblastoma gene product. Its induction in quiescent …

In senescent cells, specialized domains of transcriptionally silent senescence-associated
heterochromatic foci (SAHF), containing heterochromatin proteins such as HP1, are thought to …

Macroautophagy (hereafter referred to as autophagy) is a process in which organelles
termed autophagosomes deliver cytoplasmic constituents to lysosomes for degradation 1 . …

Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both
functions are dependent on the development of the senescent phenotype, which involves an …

Senescence is a stable proliferation arrest, associated with an altered secretory pathway,
thought to promote tumor suppression and tissue aging. While chromatin regulation and lamin …