Inference of population structure using multilocus genotype data
JK Pritchard, M Stephens, P Donnelly - Genetics, 2000 - academic.oup.com
We describe a model-based clustering method for using multilocus genotype data to infer
population structure and assign individuals to populations. We assume a model in which there …
population structure and assign individuals to populations. We assume a model in which there …
[PDF][PDF] A new statistical method for haplotype reconstruction from population data
M Stephens, NJ Smith, P Donnelly - The American Journal of Human …, 2001 - cell.com
Current routine genotyping methods typically do not provide haplotype information, which is
essential for many analyses of fine-scale molecular-genetics data. Haplotypes can be …
essential for many analyses of fine-scale molecular-genetics data. Haplotypes can be …
A new multipoint method for genome-wide association studies by imputation of genotypes
Genome-wide association studies are set to become the method of choice for uncovering
the genetic basis of human diseases. A central challenge in this area is the development of …
the genetic basis of human diseases. A central challenge in this area is the development of …
A fine-scale map of recombination rates and hotspots across the human genome
Genetic maps, which document the way in which recombination rates vary over a genome,
are an essential tool for many genetic analyses. We present a high-resolution genetic map of …
are an essential tool for many genetic analyses. We present a high-resolution genetic map of …
[HTML][HTML] The UK Biobank resource with deep phenotyping and genomic data
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic
data collected on approximately 500,000 individuals from across the United Kingdom, aged …
data collected on approximately 500,000 individuals from across the United Kingdom, aged …
Inferring coalescence times from DNA sequence data
The paper is concerned with methods for the estimation of the coalescence time (time since
the most recent common ancestor) of a sample of intraspecies DNA sequences. The …
the most recent common ancestor) of a sample of intraspecies DNA sequences. The …
[HTML][HTML] A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
BN Howie, P Donnelly, J Marchini - PLoS genetics, 2009 - journals.plos.org
Genotype imputation methods are now being widely used in the analysis of genome-wide
association studies. Most imputation analyses to date have used the HapMap as a reference …
association studies. Most imputation analyses to date have used the HapMap as a reference …
[PDF][PDF] A comparison of bayesian methods for haplotype reconstruction from population genotype data
M Stephens, P Donnelly - The American Journal of Human Genetics, 2003 - cell.com
In this report, we compare and contrast three previously published Bayesian methods for
inferring haplotypes from genotype data in a population sample. We review the methods, …
inferring haplotypes from genotype data in a population sample. We review the methods, …
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
…, U de Faire, A Hamsten, AD Morris, PJ Donnelly… - Nature …, 2012 - nature.com
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D),
we conducted a meta-analysis of genetic variants on the Metabochip, including …
we conducted a meta-analysis of genetic variants on the Metabochip, including …
Transcriptome and genome sequencing uncovers functional variation in humans
Genome sequencing projects are discovering millions of genetic variants in humans, and
interpretation of their functional effects is essential for understanding the genetic basis of …
interpretation of their functional effects is essential for understanding the genetic basis of …