We provide evidence that chitinase A from Vibrio carchariae acts as an endochitinase. The
chitinase A gene isolated from V. carchariae genome encodes 850 amino acids expressing a …

6.1. Embryonic mechanisms of NTD development 6.2. Genetics of NTD in mouse and
human Acknowledgements

Comparative proteomic methods are rapidly being applied to many different biological
systems including complex tissues. One pitfall of these methods is that in some cases, such as …

Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disorder characterized
by the accumulation of aggregates of a cellular protein, PrP, in the brain. In both human …

We have developed a novel DNA microarray-based approach for identification of the
sequence-specificity of single-stranded nucleic-acid-binding proteins (SNABPs). For verification, …

A systematic study of ‘prion protein’ genotype in cases of sporadic Creutzfeldt-Jakob disease
showing amyloid plaques staining with anti-prion protein antibody has been performed. …

Gene expression in the mammalian brain is highly complex and requires an immensely
powerful functional genomics tool to unravel it. Antisense has the potential to meet this …

Antisense offers a precise and specific means of knocking down expression of a target gene,
and is a major focus of research in neuroscience and other areas. It has application as a …

Adrenal chromaffin cells are commonly used in studies of exocytosis. Progress in
characterizing the molecular mechanisms has been slow, because no simple, high-efficiency …

The mouse mutations splotch (Sp) and curly tail (ct) both produce spinal neural tube defects
with closely similar morphology, but achieve this by different embryonic mechanisms. To …