Purpose Because current approaches to risk classification and treatment stratification for
children with neuroblastoma (NB) vary greatly throughout the world, it is difficult to directly …

Background Precise diagnosis of small-round-cell tumors is often a challenge to the
pathologist and the clinical oncologist. In Ewing's sarcomas and related peripheral primitive …

Purpose The International Neuroblastoma Risk Group (INRG) classification system was
developed to establish a consensus approach for pretreatment risk stratification. Because the …

This study reports on the specific expression of the MIC2 gene, a pseudoautosomal gene
located on the short arms of the X and Y chromosomes, on Ewing's sarcoma (ES) and …

Risk-based treatment approaches for neuroblastoma have been ongoing for decades.
However, the criteria used to define risk in various institutional and cooperative groups were …

Previous research has suggested that human herpesvirus-6 (HHV-6) may integrate into
host cell chromosomes and be vertically transmitted in the germ line, but the evidence—primarily …

Chromosomally integrated human herpesvirus 6 (ciHHV‐6) is a condition in which the
complete HHV‐6 genome is integrated into the host germ line genome and is vertically …

Purpose Survival after neuroblastoma relapse is poor. Understanding the relationship between
clinical and biologic features and outcome after relapse may help in selection of optimal …

Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides
attractive opportunities for early diagnosis, assessment of treatment response, and minimally …

Background High-dose chemotherapy with haemopoietic stem-cell rescue improves event-free
survival in patients with high-risk neuroblastoma; however, which regimen has the …