The basic helix‐loop‐helix‐leucine zipper (bHLHZip) protein Max associates with members
of the Myc family, as well as with the related proteins Mad (Mad1) and Mxi1. Whereas both …

Although the MYC oncogene has been implicated in cancer, a systematic assessment of
alterations of MYC, related transcription factors, and co-regulatory proteins, forming the …

The small constitutively expressed bHLHZip protein Max is known to form sequence-specific
DNA binding heterodimers with members of both the Myc and Mad families of bHLHZip …

The basic‐helix‐loop‐helix‐leucine zipper (bHLHZip) proteins Myc, Mad and Mnt are part of
a transcription activation/repression system involved in the regulation of cell proliferation. …

The small bHLHZip protein MAX functions at the center of a transcription factor network that
governs many aspects of cell behavior, including cell proliferation and tumorigenesis. MAX …

We have developed a model system for progression of human epithelial cells to malignancy,
using a human papillomavirus type 18 (HPV-18)-immortalized human keratinocyte cell line. …

Mutations in Tbx3 are responsible for ulnar-mammary syndrome (UMS), an autosomal
dominant disorder affecting limb, tooth, hair, apocrine gland and genital development. Tbx3 is a …

Tbx3 is a member of the T-box family of transcription factors. Mutations in Tbx3 cause ulnar-mammary
syndrome, an autosomal dominant disorder characterized by upper limb defects, …

Mnt is a Max‐interacting transcriptional repressor that has been hypothesized to function as
a Myc antagonist. To investigate Mnt function we deleted the Mnt gene in mice. Since mice …

Members of the Myc proto-oncogene family encode transcription factors that function in
multiple aspects of cell behavior, including proliferation, differentiation, transformation and …