Chromatin immunoprecipitation followed by sequencing (ChIP–seq) is a technique for
genome-wide profiling of DNA-binding proteins, histone modifications or nucleosomes. Owing to …

The 4D Nucleome Network aims to develop and apply approaches to map the structure and
dynamics of the human and mouse genomes in space and time with the goal of gaining …

Transposable elements (TEs) are abundant in the human genome, and some are capable
of generating new insertions through RNA intermediates. In cancer, the disruption of cellular …

Neurons live for decades in a postmitotic state, their genomes susceptible to DNA damage.
Here we survey the landscape of somatic single-nucleotide variants (SNVs) in the human …

Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency. …

Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced
algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on …

Recent progress in massively parallel sequencing platforms has enabled genome-wide
characterization of DNA-associated proteins using the combination of chromatin …

We have tested the specificity and utility of more than 200 antibodies raised against 57 different
histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human …

We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …