User profiles for Peter J. Harding

Peter J Harding

Manchester Metropolitan University
Verified email at mmu.ac.uk
Cited by 304

[HTML][HTML] Constitutive dimerization of the G-protein coupled receptor, neurotensin receptor 1, reconstituted into phospholipid bilayers

PJ Harding, H Attrill, J Boehringer, S Ross… - Biophysical …, 2009 - cell.com
Neurotensin receptor 1 (NTS1), a Family A G-protein coupled receptor (GPCR), was expressed
in Escherichia coli as a fusion with the fluorescent proteins eCFP or eYFP. A fluorophore-…

Real-time ultrasound segmentation, analysis and visualisation of deep cervical muscle structure

RJ Cunningham, PJ Harding… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
Despite widespread availability of ultrasound and a need for personalised muscle diagnosis
(neck/back pain-injury, work related disorder, myopathies, neuropathies), robust, online …

[HTML][HTML] Blunted angiogenesis and hypertrophy are associated with increased fatigue resistance and unchanged aerobic capacity in old overloaded mouse muscle

SB Ballak, T Busé-Pot, PJ Harding, MH Yap… - Age, 2016 - Springer
We hypothesize that the attenuated hypertrophic response in old mouse muscle is (1) partly
due to a reduced capillarization and angiogenesis, which is (2) accompanied by a reduced …

Direct analysis of a GPCR-agonist interaction by surface plasmon resonance

PJ Harding, TC Hadingham, JM McDonnell… - European Biophysics …, 2006 - Springer
Despite their clinical importance, detailed analysis of ligand binding at G-protein coupled
receptors (GPCRs) has proved difficult. Here we successfully measure the binding of a GPCR, …

Improved yield of a ligand-binding GPCR expressed in E. coli for structural studies

H Attrill, PJ Harding, E Smith, S Ross, A Watts - Protein Expression and …, 2009 - Elsevier
The G-protein coupled receptor (GPCR), rat brain neurotensin receptor type I (NTS1) is one
of a small number of GPCRs that have been successfully expressed in Escherichia coli as a …

[HTML][HTML] Foreground detection analysis of ultrasound image sequences identifies markers of motor neurone disease across diagnostically relevant skeletal muscles

K Bibbings, PJ Harding, ID Loram, N Combes… - Ultrasound in medicine …, 2019 - Elsevier
Diagnosis of motor neurone disease (MND) includes detection of small, involuntary muscle
excitations, termed fasciculations. There is need to improve diagnosis and monitoring of …

The application of deep convolutional neural networks to ultrasound for modelling of dynamic states within human skeletal muscle

RJ Cunningham, PJ Harding, ID Loram - arXiv preprint arXiv:1706.09450, 2017 - arxiv.org
This paper concerns the fully automatic direct in vivo measurement of active and passive
dynamic skeletal muscle states using ultrasound imaging. Despite the long standing medical …

An automated text mining approach for classifying mental-ill health incidents from police incident logs for data-driven intelligence

MS Haleem, L Han, PJ Harding… - 2019 IEEE international …, 2019 - ieeexplore.ieee.org
Data-driven intelligence can play a pivotal role in enhancing the effectiveness and efficiency
of police service provision. Despite of police organizations being a rich source of qualitative …

Prediction and mitigation of crush conditions in emergency evacuations

PJ Harding, M Amos, S Gwynne - Pedestrian and Evacuation Dynamics …, 2009 - Springer
Several simulation environments exist for the simulation of large-scale evacuations of buildings,
ships, or other enclosed spaces. These offer sophisticated tools for the study of human …

An early warning method for crush

PJ Harding, S Gwynne, M Amos - arXiv preprint arXiv:1008.2160, 2010 - arxiv.org
Fatal crush conditions occur in crowds with tragic frequency. Event organisers and architects
are often criticised for failing to consider the causes and implications of crush, but the reality …