Ligand: a versatile computerized approach for characterization of ligand-binding systems
PJ Munson, D Rodbard - Analytical biochemistry, 1980 - Elsevier
We have developed a general strategy and a versatile computer program for analysis of
data from ligand-binding experiments (eg, radioreceptor assay systems for hormones, …
data from ligand-binding experiments (eg, radioreceptor assay systems for hormones, …
Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.
A DeLean, PJ Munson… - American Journal of …, 1978 - journals.physiology.org
Physiological and pharmacological studies of hormones, drugs, and neurotransmitters often
generate families of sigmoidal dose-response curves. Optimally efficient data analysis …
generate families of sigmoidal dose-response curves. Optimally efficient data analysis …
Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing …
…, PJ Munson, S Listwak, J Licinio… - Proceedings of the …, 2000 - National Acad Sciences
Both stress-system activation and melancholic depression are characterized by fear,
constricted affect, stereotyped thinking, and similar changes in autonomic and neuroendocrine …
constricted affect, stereotyped thinking, and similar changes in autonomic and neuroendocrine …
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
…, A Aviv, D Levy, JM Murabito, PJ Munson… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …
Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays
…, JK Lee, V Espina, PJ Munson… - Proceedings of the …, 2003 - National Acad Sciences
Because most potential molecular markers and targets are proteins, proteomic profiling is
expected to yield more direct answers to functional and pharmacological questions than does …
expected to yield more direct answers to functional and pharmacological questions than does …
[PDF][PDF] Protein microarrays: meeting analytical challenges for clinical applications
…, D Geho, PJ Munson, L Young, J Wulfkuhle… - Cancer cell, 2003 - cell.com
Protein microarrays, one emerging class of proteomic technologies, have broad applications
for discovery and quantitative analysis. A rapidly expanding use of this technology is the …
for discovery and quantitative analysis. A rapidly expanding use of this technology is the …
Spatial proximity of translocation-prone gene loci in human lymphomas
JJ Roix, PG McQueen, PJ Munson, LA Parada… - Nature …, 2003 - nature.com
Cancer cells frequently have disease-specific chromosome rearrangements 1 , 2 , 3 , 4 . It is
poorly understood why translocations between chromosomes recur at specific breakpoints …
poorly understood why translocations between chromosomes recur at specific breakpoints …
Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus
…, YA Yu, E Wang, N Chen, RL Danner, PJ Munson… - Cancer research, 2007 - AACR
Previously, we reported that a recombinant vaccinia virus (VACV) carrying a light-emitting
fusion gene enters, replicates in, and reveals the locations of tumors in mice. A new …
fusion gene enters, replicates in, and reveals the locations of tumors in mice. A new …
NRAS mutation causes a human autoimmune lymphoproliferative syndrome
…, J Barb, PJ Munson, JM Puck, J Dale… - Proceedings of the …, 2007 - National Acad Sciences
The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates
cell proliferation, cytoskeletal organization, and other signaling networks, and is the most …
cell proliferation, cytoskeletal organization, and other signaling networks, and is the most …