Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…

Background Twin studies of bipolar affective disorder (BPD) have either been small or have
not used explicit diagnostic criteria. There has been little use of genetic model fitting and no …

Quantitative genetic research has built a strong case for the importance of genetic factors in
many complex behavioral disorders and dimensions in the domains of psychopathology, …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

• An operational criteria checklist for psychotic illness and computer programs designed to
be used in conjunction with it constitute the OPCRIT system. This provides a simple and …

Background Previous twin studies have supported a genetic contribution to the major categories
of psychotic disorders, but few of these have employed operational diagnostic criteria, …

We report analyses from a study of gene–environment interaction in adolescent depression.
The sample was selected from 1990 adolescents aged 10–20 years: those with depression …

Smoking is a leading global cause of disease and mortality 1 . We established the Oxford-GlaxoSmithKline
study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association …