Genome-wide association studies (GWAS) have identified >100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …

Most signals detected by genome-wide association studies map to non-coding sequence
and their tissue-specific effects influence transcriptional regulation. However, key tissues and …

In this study we demonstrate the potential value of Immunoglobulin G (IgG) glycosylation as
a novel prognostic biomarker of colorectal cancer (CRC). We analysed plasma IgG glycans …

The assay for transposase-accessible chromatin using sequencing (ATAC-seq) has become
the preferred method for mapping chromatin accessibility due to its time and input material …

EndoC-βH1 is emerging as a critical human β cell model to study the genetic and
environmental etiologies of β cell (dys)function and diabetes. Comprehensive knowledge of its …

Protection against antimicrobial peptides (AMPs) often involves the parallel production of
multiple, well‐characterized resistance determinants. So far, little is known about how these …

Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA),
but many patients do not respond adequately. In order to identify genetic predictors of …

Engaging young people in organisational leadership offers opportunities for them to contribute
and make a positive difference to their communities, benefitting both the young people …

Background Telemonitoring of symptoms and physiological signs has been suggested as a
means of early detection of chronic obstructive pulmonary disease (COPD) exacerbations, …

Skeletal muscle accounts for the largest proportion of human body mass, on average, and is
a key tissue in complex diseases and mobility. It is composed of several different cell and …