Substantial progress has been made toward understanding the genetic architecture,
cellular substrates, brain circuits and endophenotypic profiles of neuropsychiatric disorders, …

The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

Recent evidence implicates glutamatergic synapses as key pathogenic sites in psychiatric
disorders. Common and rare variants in the ANK3 gene, encoding ankyrin-G, have been …

Spine function requires precise control of the actin cytoskeleton. Kalirin-7, a GDP/GTP exchange
factor for Rac1, interacts with PDZ proteins such as PSD-95, colocalizing with PSD-95 …

The morphogenesis of dendritic spines, the major sites of excitatory synaptic transmission in
the brain, is important in synaptic development and plasticity. We have identified an ephrinB-…

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Synaptic spines are dynamic structures that regulate neuronal responsiveness and plasticity.
We examined the role of the schizophrenia risk factor DISC1 in the maintenance of spine …

Activity-dependent rapid structural and functional modifications of central excitatory synapses
contribute to synapse maturation, experience-dependent plasticity, and learning and …

The 5-HT 2A serotonin receptor is the most abundant serotonin receptor subtype in the cortex
and is predominantly expressed in pyramidal neurons. The 5-HT 2A receptor is a target of …

Dendritic spine morphogenesis contributes to brain function, cognition, and behavior, and is
altered in psychiatric disorders. Kalirin is a brain-specific guanine-nucleotide exchange …