Species of malaria parasite that infect rodents have long been used as models for malaria
disease research. Here we report the whole-genome shotgun sequence of one species, …

Malaria parasites, and other parasitic protists of the Phylum Apicomplexa, carry a plastid-like
genome with greatly reduced sequence complexity. This 35 kb DNA circle resembles the …

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated with …

Plasmodium vivax causes over 100 million clinical infections each year. Primarily because
of the lack of a suitable culture system, our understanding of the biology of this parasite lags …

Functions have yet to be defined for the majority of genes of Plasmodium falciparum, the
agent responsible for the most serious form of human malaria. Here we report changes in P. …

Malaria genetic variation has been extensively characterized, but the level of epigenetic
plasticity remains largely unexplored. Here we provide a comprehensive characterization of …

Background Artemisinin resistance in Plasmodium falciparum malaria has emerged in Western
Cambodia. This is a major threat to global plans to control and eliminate malaria as the …

Achievement of malaria elimination requires development of novel strategies interfering with
parasite transmission, including targeting the parasite sexual stages (gametocytes). The …

Malaria parasites are obligate intracellular parasites whose invasive stages select and invade
the unique host cell in which they can develop with exquisite specificity and efficacy. Most …

Heterochromatin-dependent gene silencing is central to the adaptation and survival of
Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood …