User profiles for Peter R. Shepherd
 | Peter R ShepherdVerified email at auckland.ac.nz Cited by 17721 |
Glucose transporters and insulin action—implications for insulin resistance and diabetes mellitus
PR Shepherd, BB Kahn - New England journal of medicine, 1999 - Mass Medical Soc
Insulin was discovered more than 75 years ago, but only recently have we begun to understand
the mechanisms by which insulin promotes the uptake of glucose into cells. This review …
the mechanisms by which insulin promotes the uptake of glucose into cells. This review …
The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
…, J Barnett, NR Leslie, S Cheng, PR Shepherd… - The Journal of cell …, 2004 - rupress.org
Insulin-like growth factors elicit many responses through activation of phosphoinositide 3-OH
kinase (PI3K). The tuberous sclerosis complex (TSC1-2) suppresses cell growth by …
kinase (PI3K). The tuberous sclerosis complex (TSC1-2) suppresses cell growth by …
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on …
…, DJ Withers, DR Alessi, PR SHEPHERD - Biochemical …, 1999 - portlandpress.com
Growth factor induced activation of phosphoinositide 3-kinase and protein kinase B (PKB)
leads to increased activity of the mammalian target of rapamycin (mTOR). This subsequently …
leads to increased activity of the mammalian target of rapamycin (mTOR). This subsequently …
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
PR Shepherd, DJ Withers, K Siddle - Biochemical Journal, 1998 - portlandpress.com
Insulin plays a key role in regulating a wide range of cellular processes. However, until
recently little was known about the signalling pathways that are involved in linking the insulin …
recently little was known about the signalling pathways that are involved in linking the insulin …
PI 3-kinase p110β: a new target for antithrombotic therapy
…, PE Thompson, GD Smith, PR Shepherd… - Nature medicine, 2005 - nature.com
Platelet activation at sites of vascular injury is essential for the arrest of bleeding; however,
excessive platelet accumulation at regions of atherosclerotic plaque rupture can result in the …
excessive platelet accumulation at regions of atherosclerotic plaque rupture can result in the …
[HTML][HTML] Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.
PR Shepherd, L Gnudi, E Tozzo, H Yang… - Journal of Biological …, 1993 - Elsevier
To gain insight into the molecular pathogenesis of obesity and specifically the role of
nutrient partitioning in the development of obesity, we overexpressed the insulin-responsive …
nutrient partitioning in the development of obesity, we overexpressed the insulin-responsive …
[HTML][HTML] Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status
…, LGD Fryer, D Carling, PR Shepherd - Journal of Biological …, 2004 - ASBMB
The mammalian target of rapamycin (mTOR) is a key regulator of protein translation.
Signaling via mTOR is increased by growth factors but decreased during nutrient deprivation. …
Signaling via mTOR is increased by growth factors but decreased during nutrient deprivation. …
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling
…, SP Jackson, N Daniele, PR Shepherd - Biochemical …, 2007 - portlandpress.com
Recent genetic knock-in and pharmacological approaches have suggested that, of class IA
PI3Ks (phosphatidylinositol 3-kinases), it is the p110α isoform (PIK3CA) that plays the …
PI3Ks (phosphatidylinositol 3-kinases), it is the p110α isoform (PIK3CA) that plays the …
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement …
PR Shepherd, BT Nave, K Siddle - Biochemical Journal, 1995 - portlandpress.com
We have investigated the involvement of phosphoinositide (PI) 3-kinase and p70 ribosomal
protein-S6 kinase (p70s6k) in mediating insulin stimulation of glycogen synthesis in 3T3-L1 …
protein-S6 kinase (p70s6k) in mediating insulin stimulation of glycogen synthesis in 3T3-L1 …
[HTML][HTML] The role of phosphoinositide 3-kinase C2α in insulin signaling
…, F Fostira, MQ Fang, R Cazzolli, PR Shepherd… - Journal of Biological …, 2007 - ASBMB
The members of the class II phosphoinositide 3-kinase (PI3K) family can be activated by
several stimuli, indicating that these enzymes can regulate many intracellular processes. …
several stimuli, indicating that these enzymes can regulate many intracellular processes. …