[HTML][HTML] Influence of hyaluronic acid transitions in tumor microenvironment on glioblastoma malignancy and invasive behavior

JWE Chen, S Pedron, P Shyu, Y Hu, JN Sarkaria… - Frontiers in …, 2018 - frontiersin.org
The extracellular matrix (ECM) is critical in tumor growth and invasive potential of cancer
cells. In glioblastoma tumors, some components of the native brain ECM such as hyaluronic …

Dropping in on lipid droplets: insights into cellular stress and cancer

P Shyu Jr, XFA Wong, K Crasta, G Thibault - Bioscience reports, 2018 - portlandpress.com
Lipid droplets (LD) have increasingly become a major topic of research in recent years following
its establishment as a highly dynamic organelle. Contrary to the initial view of LDs being …

[HTML][HTML] Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins

P Shyu Jr, BSH Ng, N Ho, R Chaw, YL Seah… - Scientific reports, 2019 - nature.com
Phospholipid homeostasis in biological membranes is essential to maintain functions of
organelles such as the endoplasmic reticulum. Phospholipid perturbation has been associated …

[HTML][HTML] Cytotoxicity of probiotics from Philippine commercial dairy products on cancer cells and the effect on expression of cfos and cjun early apoptotic-promoting …

PT Shyu, GG Oyong, EC Cabrera - BioMed research international, 2014 - hindawi.com
This study determined cytotoxicity of probiotic Lactobacillus spp. from Philippine dairy products
on cancer cells and normal fibroblasts and their effects on expression of early apoptotic-…

[HTML][HTML] A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice

…, B Bisikirska, CS Lin, Y Huang, PT Shyu… - The Journal of …, 2022 - Am Soc Clin Investig
The various functions of the skeleton are influenced by extracellular cues, hormones, and
neurotransmitters. One type of neuronal regulation favors bone mass accrual by inhibiting …

Mechanical loading and parathyroid hormone effects and synergism in bone vary by site and modeling/remodeling regime

ST Robinson, PT Shyu, XE Guo - Bone, 2021 - Elsevier
Intermittent injections of parathyroid hormone (PTH) and mechanical loading are both known
to effect a net increase in bone mass. Fundamentally, bone metabolism can be divided into …

The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis

WS Yap, P Shyu Jr, ML Gaspar, SA Jesch… - Journal of cell …, 2020 - journals.biologists.com
Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat
storage-inducing transmembrane (FIT; also known as FITM) family induces LD formation. Here…

Avalanche criticality during compression of porcine cortical bone of different ages

J Baró, P Shyu, S Pang, IM Jasiuk, E Vives, EKH Salje… - Physical Review E, 2016 - APS
Crack events developed during uniaxial compression of cortical bones cut from femurs of
developing pigs of several ages (4, 12, and 20 weeks) generate avalanches. These …

Deproteinization of cortical bone: Effects of different treatments

FY Su, S Pang, YTT Ling, P Shyu, E Novitskaya… - Calcified tissue …, 2018 - Springer
Bone is a biological composite material having collagen and mineral as its main constituents.
In order to better understand the arrangement of the mineral phase in bone, porcine …

Do changes in the discount rate and Fed funds rate affect financial market returns?

MJ Seiler, P Shyu, JL Sharma - Managerial Finance, 1998 - emerald.com
Reviews previous research on the announcement effects of changes in US Federal Reserve
policies and presents a study of the impact of federal funds rate and discount rate changes …