The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC-…

BACKGROUND Rapid and correct diagnosis of acute myocardial infarction (MI) has an
important impact on patient treatment and prognosis. We compared the diagnostic performance …

Small noncoding microRNAs (miRNA) regulate the expression of target mRNAs by repressing
their translation or orchestrating their sequence-specific degradation. In this study, we …

Early cancer detection and disease stratification or classification are critical to successful
treatment. Accessible, reliable, and informative cancer biomarkers can be medically valuable …

MicroRNAs (miRNAs) are ubiquitously expressed small non-coding RNAs that, in most cases,
negatively regulate gene expression at the post-transcriptional level. miRNAs are involved …

In solid tumors, cancer stem cells (CSCs) or tumor-initiating cells (TICs) are often found in
hypoxic niches. Nevertheless, the influence of hypoxia on TICs is poorly understood. Using …

Heterozygous mutations in NADP ‐dependent isocitrate dehydrogenases ( IDH ) define the
large majority of diffuse gliomas and are associated with hypermethylation of DNA and …

Patient-based cancer models are essential tools for studying tumor biology and for the
assessment of drug responses in a translational context. We report the establishment a large …

Interactions between transmembrane helices play a key role in almost all cellular processes
involving membrane proteins. We have investigated helix-helix interactions in lipid bilayers …

While the autophagic process is mainly regulated at the post-translational level, a growing
body of evidence suggests that autophagy might also be regulated at the transcriptional level. …