Despite the established dogma of central nervous system (CNS) immune privilege, neuroimmune
interactions play an active role in diverse neurological disorders. However, the precise …

Somatic mutations in DNMT3A, which encodes a de novo DNA methyltransferase, are found
in ∼30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …

Protein abundance and phosphorylation convey important information about pathway activity
and molecular pathophysiology in diseases including cancer, providing biological insight, …

Sleep loss is associated with cognitive decline in the aging population and is a risk factor for
Alzheimer’s disease (AD). Considering the crucial role of immunomodulating genes such as …

Acute myeloid leukemia (AML) is characterized by dysregulated gene expression and
abnormal patterns of DNA methylation; the relationship between these events is unclear. Many …

Recent advances in mass spectrometry (MS) have enabled extensive analysis of cancer
proteomes. Here, we employed quantitative proteomics to profile protein expression across 24 …

Improvements in mass spectrometry (MS)-based peptide sequencing provide a new opportunity
to determine whether polymorphisms, mutations, and splice variants identified in cancer …

We have developed a deep-scale proteome and phosphoproteome database from 44
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 healthy …

Bottom-up proteomics relies on the use of proteases and is the method of choice for identifying
thousands of protein groups in complex samples. Top-down proteomics has been shown …

The endogenous signaling molecule S-nitrosoglutathione (GSNO) and other S-nitrosylating
agents can cause full maturation of the abnormal gene product ΔF508 cystic fibrosis (CF) …