Three isozymes of nitric oxide (NO) synthase (EC 1.14.13.39) have been identified and the
cDNAs for these enzymes isolated. In humans, isozymes I (in neuronal and epithelial cells), II …

The role of nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase (iNOS)
is very complex. Induction of iNOS expression and hence NO production has been …

The integrity of peripheral nerves relies on communication between axons and Schwann
cells. The axonal signals that ensure myelin maintenance are distinct from those that direct …

The differentiation of follicular dendritic cells (FDC) is essential to the remarkable
microanatomic plasticity of lymphoid follicles. Here we show that FDC arise from ubiquitous …

N01_, the smallest known bioactive product of mammalian cells, can be produced by most
cell types. Despite its almost ubiquitous occurrence, this simple molecule can act in a fairly …

New-variant Creutzfeldt–Jakob disease and scrapie are typically initiated by extracerebral
exposure to the causative agent, and exhibit early prion replication in lymphoid organs 1, 2. In …

Hypertension is a side effect of systemically administered glucocorticoids, but the underlying
molecular mechanism remains poorly understood. Ingestion of dexamethasone by rats …

The occurrence of multiple strains of prions may reflect conformational variability of PrP Sc ,
a disease-associated, aggregated variant of the cellular prion protein, PrP C . Here we used …

This study was designed to elucidate whether nitric oxide (NO) controls norepinephrine (NE)
release from sympathetic nerves of the rat heart. Hearts were perfused in the Langendorff …

Peripheral infection is the natural route of transmission in most prion diseases 1 . Peripheral
prion infection is followed by rapid prion replication in lymphoid organs, neuroinvasion 2 …