Organoids are biomimetic tissue models comprising multiple cell types and cell states. Post-translational
modification (PTM) signaling networks control cellular phenotypes and are …

Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet
these processes are often studied separately. To functionally map how cell-intrinsic and cell-…

Despite the widespread adoption of organoids as biomimetic tissue models, methods to
comprehensively analyze cell-type-specific post-translational modification (PTM) signaling …

Patient-derived organoids (PDOs) can model personalized therapy responses; however,
current screening technologies cannot reveal drug response mechanisms or how tumor …

Hepatocellular Carcinoma (HCC) is increasing in incidence worldwide and requires new
approaches to therapy. The combination of anti-angiogenic drug therapy and radiotherapy is …

Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet
these processes are often studied separately. To functionally map how cell-intrinsic and cell-…

Patient-derived organoids (PDOs) can model personalized therapy responses, however
current screening technologies cannot reveal drug response mechanisms or study how tumor …

Organoids are powerful biomimetic tissue models. Despite their widespread adoption, methods
to analyse cell-type specific post-translational modification (PTM) signalling networks in …

Chemotherapy, the standard of care treatment for cancer patients with advanced disease,
has been increasingly recognised to activate host immune responses to produce durable …

Colorectal cancer (CRC) is a devastating disease that kills ~700,000 people worldwide
annually. Current immunotherapies struggle against both microsatellite stable (MSS) disease …