Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin
into chromatin loops 1 , 2 and topologically associated domains 3 , 4 , 5 , 6 , which have …

The iron-sulfur-containing DNA helicases XPD, FANCJ, DDX11, and RTEL represent a small
subclass of superfamily 2 helicases. XPD and FANCJ have been connected to the genetic …

Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin
complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is …

10.7554/eLife.26980.001 Recent genome analyses have identified recurrent mutations in
the cohesin complex in a wide range of human cancers. Here we demonstrate that the most …

10.7554/eLife.43333.001 Targeted cancer therapy is based on exploiting selective dependencies
of tumor cells. By leveraging recent functional screening data of cancer cell lines we …

Cohesion between sister chromatids is essential for faithful chromosome segregation. In
budding yeast, the acetyltransferase Eco1/Ctf7 establishes cohesion during DNA replication in …

In the mammalian embryo, epiblast cells must exit the naïve state and acquire formative
pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells (ESCs), …

Chromosome segregation depends on sister chromatid cohesion which is established by
cohesin during DNA replication. Cohesive cohesin complexes become acetylated to prevent …

Although splicing is essential for the expression of most eukaryotic genes, inactivation of
splicing factors causes specific defects in mitosis. The molecular cause of this defect is unknown…

The cohesin subunit STAG2 has emerged as a recurrently inactivated tumor suppressor in
human cancers. Using candidate approaches, recent studies have revealed a synthetic lethal …