Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment.
Here, we characterize four CAF subsets in breast cancer with distinct properties and levels of …

At the stage of carcinoma in situ, the basement membrane (BM) segregates tumor cells from
the stroma. This barrier must be breached to allow dissemination of the tumor cells to …

The cellular and molecular programs driving T-cell marginalization in solid tumors remain
unclear. Here, we describe two CAF populations associated with T-cell exclusion in human …

This work identifies a novel lipid–associated macrophage subpopulation with immune
suppressive functions, offering new leads for therapeutic interventions in triple-negative breast …

High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular subtypes.
The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures, is …

Tumor associated macrophages (TAMs), which differentiate from circulating monocytes, are
pervasive across human cancers and comprise heterogeneous populations. The …

T cells that recognize tumor antigens are crucial for mounting antitumor immune responses.
Induction of antitumor T cells in immunogenic tumors depends on STING, the intracellular …

The functions and transcriptional profiles of dendritic cells (DCs) result from the interplay
between ontogeny and tissue imprinting. How tumors shape human DCs is unknown. Here we …

Innate immune cells adjust to microbial and inflammatory stimuli through a process termed
environmental plasticity, which links a given individual stimulus to a unique activated state. …

A major challenge in cancer research is the complexity of the tumor microenvironment, which
includes the host immunological setting. Inspired by the emerging technology of organ-on-…