User profiles for Philip Cowen
 | Philip CowenProfessor of Psychopharmacology Verified email at psych.ox.ac.uk Cited by 51095 |
Effect of acute antidepressant administration on negative affective bias in depressed patients
…, PJ Cowen - American Journal of …, 2009 - Am Psychiatric Assoc
Objective: Acute administration of an antidepressant increases positive affective processing
in healthy volunteers, an effect that may be relevant to the therapeutic actions of these …
in healthy volunteers, an effect that may be relevant to the therapeutic actions of these …
Brain serotonin1A receptor binding measured by positron emission tomography with [11C] WAY-100635: effects of depression and antidepressant treatment
Background Pharmacological and postmortem investigations suggest that patients with major
depressive disorder have alterations in function or density of brain serotonin 1A (5-HT 1A ) …
depressive disorder have alterations in function or density of brain serotonin 1A (5-HT 1A ) …
Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition
OBJECTIVE: Antidepressants that inhibit the reuptake of serotonin (SSRIs) or norepinephrine
(SNRIs) are effective in the treatment of disorders such as depression and anxiety. …
(SNRIs) are effective in the treatment of disorders such as depression and anxiety. …
Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action
BackgroundThe neuropharmacological actions of antidepressants are well characterised
but our understanding of how these changes translate into improved mood are still emerging.…
but our understanding of how these changes translate into improved mood are still emerging.…
[HTML][HTML] Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers
Objectives The present study explored the effects of two prebiotics on the secretion of the
stress hormone, cortisol and emotional processing in healthy volunteers. Methods Forty-five …
stress hormone, cortisol and emotional processing in healthy volunteers. Methods Forty-five …
Antidepressant drug treatment modifies the neural processing of nonconscious threat cues
BACKGROUND: The amygdala is believed to play a key role in processing emotionally
salient, threat-relevant, events that require further online processing by cortical regions. …
salient, threat-relevant, events that require further online processing by cortical regions. …
How do antidepressants work? New perspectives for refining future treatment approaches
Most currently available antidepressants target monoamine neurotransmitter function.
However, a purely neurotransmitter-based explanation for antidepressant drug action is …
However, a purely neurotransmitter-based explanation for antidepressant drug action is …
Immunogold-silver staining: new method of immunostaining with enhanced sensitivity.
CS Holgate, P Jackson, PN Cowen… - … of Histochemistry & …, 1983 - journals.sagepub.com
A new method for demonstrating antigens in paraffin sections of formol sublimate-fixed
tissue is described that utilizes an "indirect" immunohistological technique employing …
tissue is described that utilizes an "indirect" immunohistological technique employing …
[HTML][HTML] What has serotonin to do with depression?
PJ Cowen, M Browning - World Psychiatry, 2015 - ncbi.nlm.nih.gov
The “serotonin hypothesis” of clinical depression is almost 50 years old. At its simplest, the
hypothesis proposes that diminished activity of serotonin pathways plays a causal role in the …
hypothesis proposes that diminished activity of serotonin pathways plays a causal role in the …
Increased salivary cortisol after waking in depression
Z Bhagwagar, S Hafizi, PJ Cowen - Psychopharmacology, 2005 - Springer
Rationale Cortisol hypersecretion is regarded as important in the pathophysiology of major
depression. However, recent studies in community-based samples have been inconclusive. …
depression. However, recent studies in community-based samples have been inconclusive. …