The genetic transfer of antigen receptors provides a means to rapidly generate autologous
tumor-reactive T lymphocytes. However, recognition of tumor antigens by cytotoxic T cells is …

Although it is well established that tumors initiate an angiogenic switch, the molecular basis
of this process remains incompletely understood. Here we show that the miRNA miR-132 …

The role for inhibitory Fc gamma receptors class IIb (FcγRIIb) in the onset, progression and
severity of several animal models of autoimmune diseases is well established. By contrast, …

Mutations in gene RASA1 have been historically associated with capillary malformation–arteriovenous
malformation, but sporadic reports of lymphatic involvement have yet to be …

RASA1 (also known as p120 RasGAP) is a Ras GTPase–activating protein that functions as
a regulator of blood vessel growth in adult mice and humans. In humans, RASA1 mutations …

TCR and CD28 costimulatory receptor-cooperative induction of T cell IL-2 secretion is
dependent upon activation of mitogen-activated protein (MAP) kinases. Using yeast-hybrid …

Capillary malformation-arteriovenous malformation (CM-AVM) is an autosomal dominant
vascular disorder that is associated with inherited inactivating mutations of the RASA1 gene in …

The hepatic hormone hepcidin is a key regulator of systemic iron metabolism. Its expression
is largely regulated by 2 signaling pathways: the “iron-regulated” bone morphogenetic …

Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis
is now known to regulate a wide range of eukaryotic cell processes. Among these are …

Inactivation of the small guanosine triphosphate–binding protein Ras during receptor signal
transduction is mediated by Ras guanosine triphosphatase (GTPase)–activating proteins (…