Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be
abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we …

Background Two brain regions often implicated in schizophrenia are the dorsolateral prefrontal
cortex (DLPFC) and the hippocampal formation (HF). It has been hypothesized that the …

OBJECTIVE: Disturbed neuronal interactions may be involved in schizophrenia because it
is without clear regional pathology. Aberrant connectivity is further suggested by theoretical …

Using multimodal neuroimaging in humans, we demonstrate specific interactions between
prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution …

Objective To investigate the neural substrate of premenstrual dysphoric disorder (PMDD),
the authors used [ 15 O]H 2 O positron emission tomography (PET) regional cerebral blood …

Mutations in GBA, the gene encoding glucocerebrosidase, the enzyme deficient in Gaucher
disease, are common risk factors for Parkinson disease, as patients with Parkinson disease …

To clarify the neural systems deployed by individual subjects during working memory (WM),
we collected functional neuroimaging data from healthy subjects, and constructed a model …

Past studies in rodents have demonstrated circannual variation in central dopaminergic
activity as well as a host of compelling interactions between melatonin—a scotoperiod-…

Before their disappearance from the fossil record approximately 40,000 years ago, Neanderthals,
the ancient hominin lineage most closely related to modern humans, interbred with …

Dysregulation of dopamine systems has been considered a foundational driver of
pathophysiological processes in schizophrenia, an illness characterized by diverse domains of …