A single–cell type transcriptomics map of human tissues
Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …
[HTML][HTML] Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
…, M Germain, W Schrottmaier, P Dusart… - nature …, 2023 - nature.com
Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious
short- and long-term complications. In clinical practice, there is a need for improved plasma …
short- and long-term complications. In clinical practice, there is a need for improved plasma …
[PDF][PDF] A human adipose tissue cell-type transcriptome atlas
The importance of defining cell-type-specific genes is well acknowledged. Technological
advances facilitate high-resolution sequencing of single cells, but practical challenges remain. …
advances facilitate high-resolution sequencing of single cells, but practical challenges remain. …
Human serum albumin-based probes for molecular targeting of macrophage scavenger receptors
M Ahmed, R Baumgartner, S Aldi, P Dusart… - International journal …, 2019 - Taylor & Francis
Background: Inflammation and accumulation of macrophages are key features of unstable
atherosclerotic plaques. The ability of macrophages to take up molecular probes can be …
atherosclerotic plaques. The ability of macrophages to take up molecular probes can be …
[PDF][PDF] A systems-based map of human brain cell-type enriched genes and malignancy-associated endothelial changes
Changes in the endothelium of the cerebral vasculature can contribute to inflammatory,
thrombotic, and malignant disorders. The importance of defining cell-type-specific genes and …
thrombotic, and malignant disorders. The importance of defining cell-type-specific genes and …
Identification of endothelial proteins in plasma associated with cardiovascular risk factors
…, L Sanchez-Rivera, L Enge, P Dusart… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Endothelial cell (EC) dysfunction is a well-established response to cardiovascular
disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC …
disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC …
[HTML][HTML] A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein
P Dusart, L Fagerberg, L Perisic, M Civelek, E Struck… - Scientific reports, 2018 - nature.com
The intermediate filament protein nestin is expressed during embryonic development, but
considered largely restricted to areas of regeneration in the adult. Here, we perform a body-…
considered largely restricted to areas of regeneration in the adult. Here, we perform a body-…
Total synthesis of (±)-aspercyclide A and its C19 methyl ether
JL Carr, DA Offermann, MD Holdom, P Dusart… - Chemical …, 2010 - pubs.rsc.org
The total syntheses of (±)-aspercyclide A (1) and its C19 methyl ether (15a) featuring Heck–
Mizoroki macrocyclisation to form the 11-membered (E)-styrenyl biaryl ether lactone core are …
Mizoroki macrocyclisation to form the 11-membered (E)-styrenyl biaryl ether lactone core are …
[HTML][HTML] Molecular imaging of a new multimodal microbubble for adhesion molecule targeting
M Ahmed, B Gustafsson, S Aldi, P Dusart, G Egri… - Cellular and molecular …, 2019 - Springer
Introduction Inflammation is an important risk-associated component of many diseases and
can be diagnosed by molecular imaging of specific molecules. The aim of this study was to …
can be diagnosed by molecular imaging of specific molecules. The aim of this study was to …
Global Transcriptome Analysis Reveals Distinct Phases of the Endothelial Response to TNF
…, JO Odeberg, ML Kuijjer, PJ Dusart… - The Journal of …, 2024 - journals.aai.org
The vascular endothelium acts as a dynamic interface between blood and tissue. TNF-a, a
major regulator of inflammation, induces endothelial cell (EC) transcriptional changes, the …
major regulator of inflammation, induces endothelial cell (EC) transcriptional changes, the …