A single–cell type transcriptomics map of human tissues

…, B Katona, E Sjöstedt, L Butler, J Odeberg, P Dusart… - Science …, 2021 - science.org
Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …

[HTML][HTML] Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism

…, M Germain, W Schrottmaier, P Dusart… - nature …, 2023 - nature.com
Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious
short- and long-term complications. In clinical practice, there is a need for improved plasma …

[PDF][PDF] A human adipose tissue cell-type transcriptome atlas

…, J Odeberg, C Lindskog, F Ponten, M Uhlen, PJ Dusart… - Cell reports, 2022 - cell.com
The importance of defining cell-type-specific genes is well acknowledged. Technological
advances facilitate high-resolution sequencing of single cells, but practical challenges remain. …

Human serum albumin-based probes for molecular targeting of macrophage scavenger receptors

M Ahmed, R Baumgartner, S Aldi, P Dusart… - International journal …, 2019 - Taylor & Francis
Background: Inflammation and accumulation of macrophages are key features of unstable
atherosclerotic plaques. The ability of macrophages to take up molecular probes can be …

[PDF][PDF] A systems-based map of human brain cell-type enriched genes and malignancy-associated endothelial changes

P Dusart, BM Hallström, T Renne, J Odeberg, M Uhlén… - Cell reports, 2019 - cell.com
Changes in the endothelium of the cerebral vasculature can contribute to inflammatory,
thrombotic, and malignant disorders. The importance of defining cell-type-specific genes and …

Identification of endothelial proteins in plasma associated with cardiovascular risk factors

…, L Sanchez-Rivera, L Enge, P Dusart… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Endothelial cell (EC) dysfunction is a well-established response to cardiovascular
disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC …

[HTML][HTML] A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein

P Dusart, L Fagerberg, L Perisic, M Civelek, E Struck… - Scientific reports, 2018 - nature.com
The intermediate filament protein nestin is expressed during embryonic development, but
considered largely restricted to areas of regeneration in the adult. Here, we perform a body-…

Total synthesis of (±)-aspercyclide A and its C19 methyl ether

JL Carr, DA Offermann, MD Holdom, P Dusart… - Chemical …, 2010 - pubs.rsc.org
The total syntheses of (±)-aspercyclide A (1) and its C19 methyl ether (15a) featuring Heck–
Mizoroki macrocyclisation to form the 11-membered (E)-styrenyl biaryl ether lactone core are …

[HTML][HTML] Molecular imaging of a new multimodal microbubble for adhesion molecule targeting

M Ahmed, B Gustafsson, S Aldi, P Dusart, G Egri… - Cellular and molecular …, 2019 - Springer
Introduction Inflammation is an important risk-associated component of many diseases and
can be diagnosed by molecular imaging of specific molecules. The aim of this study was to …

Global Transcriptome Analysis Reveals Distinct Phases of the Endothelial Response to TNF

…, JO Odeberg, ML Kuijjer, PJ Dusart… - The Journal of …, 2024 - journals.aai.org
The vascular endothelium acts as a dynamic interface between blood and tissue. TNF-a, a
major regulator of inflammation, induces endothelial cell (EC) transcriptional changes, the …