HuR, an RNA binding protein, binds to adenine- and uridine-rich elements (ARE) in the 3′-untranslated
region (UTR) of target mRNAs, regulating their stability and translation. HuR is …

Dye-decolorizing peroxidases (DyPs) comprise a new family of heme peroxidases, which
has received much attention due to their potential applications in lignin degradation. A new …

Musashi-1 (MSI1) is an RNA-binding protein that acts as a translation activator or repressor
of target mRNAs. The best-characterized MSI1 target is Numb mRNA, whose encoded …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other SARS-related
CoVs encode 3 tandem macrodomains within nonstructural protein 3 (nsp3). The first …

Amphipathic helices in membrane proteins that interact with the hydrophobic/hydrophilic
interface of the lipid bilayer have been difficult to structurally characterize. Here, the backbone …

Risdiplam is the first approved small-molecule splicing modulator for the treatment of spinal
muscular atrophy (SMA). Previous studies demonstrated that risdiplam analogues have two …

During eukaryotic translation initiation, eIF3 binds the solvent-accessible side of the 40S
ribosome and recruits the gate-keeper protein eIF1 and eIF5 to the decoding center. This is …

Background The Musashi (MSI) family of RNA-binding proteins is best known for the role in
post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human …

Influenza A virus M2 protein is known to form acid-activated, proton-selective, amantadine-sensitive
channels. We directly measured proton uptake in vesicles containing reconstituted …

Purified M2 protein from the Udorn strain of influenza virus was reconstituted into planar lipid
bilayers from liposomes. In 1mM HCl, the single-channel conductance was measured as 6 …