In sexual populations, beneficial mutations that occur in different lineages may be recombined
into a single lineage. In asexual populations, however, clones that carry such alternative …

Most mutations are likely to be deleterious, and so the spontaneous mutation rate is generally
held at a very low value 1 . Nonetheless, evolutionary theory predicts that high mutation …

Natural selection can adjust the rate of mutation in a population by acting on allelic variation
affecting processes of DNA replication and repair. Because mutation is the ultimate source …

During 1998, severe outbreaks of influenza were observed in four swine herds in the United
States. This event was unique because the causative agents, H3N2 influenza viruses, are …

Mutator genotypes with increased mutation rates may be especially important in microbial
evolution if genetic adaptation is generally limited by the supply of mutations. In experimental …

In asexual populations, beneficial mutations that occur in different lineages compete with
one another. This phenomenon, known as clonal interference, ensures that those beneficial …

Beneficial mutations are intuitively relevant to understanding adaptation [1–3], yet not all
beneficial mutations are of consequence to the long-term evolutionary outcome of adaptation. …

We discuss the dynamics of adaptive evolution in asexual (clonal) populations. The classical
‘periodic selection’ model of clonal evolution assumed that beneficial mutations are very …

An important problem in microbial ecology is to identify those phenotypic attributes that are
responsible for competitive fitness in a particular environment. Thousands of papers have …

Experimental evolution involves severe, periodic reductions in population size when fresh
media are inoculated during serial transfer. These bottlenecks affect the dynamics of evolution…