User profiles for Philip J. B. Koeck
 | Philip KoeckKTH Royal Institute of Technology Verified email at kth.se Cited by 1243 |
Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin
…, BR Johansson, PJB Koeck… - Proceedings of the …, 2012 - National Acad Sciences
MUC2, the major colonic mucin, forms large polymers by N-terminal trimerization and C-terminal
dimerization. Although the assembly process for MUC2 is established, it is not known …
dimerization. Although the assembly process for MUC2 is established, it is not known …
The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II
…, CO Samuelsen, PJB Koeck… - Proceedings of the …, 2006 - National Acad Sciences
CDK8 (cyclin-dependent kinase 8), along with CycC, Med12, and Med13, form a repressive
module (the Cdk8 module) that prevents RNA polymerase II (pol II) interactions with Mediator…
module (the Cdk8 module) that prevents RNA polymerase II (pol II) interactions with Mediator…
[HTML][HTML] Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
Protein misfolding and aggregation is increasingly being recognized as a cause of disease.
In Alzheimer’s disease the amyloid-β peptide (Aβ) misfolds into neurotoxic oligomers and …
In Alzheimer’s disease the amyloid-β peptide (Aβ) misfolds into neurotoxic oligomers and …
Amyloid fibril formation of Arctic amyloid-β 1–42 peptide is efficiently inhibited by the BRICHOS domain
…, C Ingeborg Jegerschöld, P JB Koeck… - ACS Chemical …, 2022 - ACS Publications
Amyloid-β peptide (Aβ) aggregation is one of the hallmarks of Alzheimer’s disease (AD).
Mutations in Aβ are associated with early onset familial AD, and the Arctic mutant E22G (Aβ arc …
Mutations in Aβ are associated with early onset familial AD, and the Arctic mutant E22G (Aβ arc …
[HTML][HTML] Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers
Most MUC5B mucin polymers in the upper airways of humans and pigs are produced by
submucosal glands. MUC5B forms N-terminal covalent dimers that are further packed into …
submucosal glands. MUC5B forms N-terminal covalent dimers that are further packed into …
Single-particle cryoelectron microscopy analysis reveals the HIV-1 spike as a tripod structure
The HIV-1 spike is a trimer of the transmembrane gp41 and the peripheral gp120 subunit
pair. It is activated for virus–cell membrane fusion by binding sequentially to CD4 and to a …
pair. It is activated for virus–cell membrane fusion by binding sequentially to CD4 and to a …
[HTML][HTML] Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly
…, M Bäckström, E Thomsson, PJB Koeck… - Journal of molecular …, 2014 - Elsevier
MUC2 is the major gel-forming mucin of the colon forming a protective gel barrier organized
into an inner stratified and an outer loose layer. The MUC2 N-terminus (D1-D2-D′D3 …
into an inner stratified and an outer loose layer. The MUC2 N-terminus (D1-D2-D′D3 …
[HTML][HTML] Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue
Proteins can self-assemble into amyloid fibrils or amorphous aggregates and thereby cause
disease. Molecular chaperones can prevent both these types of protein aggregation, but to …
disease. Molecular chaperones can prevent both these types of protein aggregation, but to …
[HTML][HTML] Structural model of dodecameric heat-shock protein Hsp21: Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the …
Small heat-shock proteins (sHsps) prevent aggregation of thermosensitive client proteins in
a first line of defense against cellular stress. The mechanisms by which they perform this …
a first line of defense against cellular stress. The mechanisms by which they perform this …
Subunit arrangement in the dodecameric chloroplast small heat shock protein Hsp21
W Lambert, PJB Koeck, E Ahrman, P Purhonen… - Protein …, 2011 - Wiley Online Library
… Philip JB Koeck … Philip JB Koeck … Images were recorded, using a Philips CM 120 microscope
at 120 kV and a magnification of 60,000 times, onto Kodak SO-163 films and digitized with a …
at 120 kV and a magnification of 60,000 times, onto Kodak SO-163 films and digitized with a …