Most excitatory transmission in the brain is mediated by the AMPA receptor subtype of the
ionotropic glutamate receptors. In many neurological diseases, synapse structure and AMPA …

Microglia interact with neurons to facilitate synapse plasticity; however, signal(s) contributing
to microglia activation for synapse elimination in pathology are not fully understood. Here, …

Hyperactivity of microglia and loss of functional circuitry is a common feature of many
neurological disorders including those induced or exacerbated by inflammation. Herein, we …

Accumulating evidence supports the idea that synapses are tripartite, whereby perisynaptic
astrocytes modulate both pre‐ and postsynaptic function. Although some of these features …

… Micrographs were taken using a Philips CM100 electron microscope at 100 kV and a Fastscan
… Micrographs were taken using a Philips CM120 electron microscope at 80 kV and a 1 K …

Brain trauma can disrupt synaptic connections, and this in turn can prompt axons to sprout
and form new connections. If these new axonal connections are aberrant, hyperexcitability …

CX 546, an allosteric positive modulator of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic
acid‐type ionotropic glutamate receptors (AMPARs), belongs to a drug class called …

Microglia interact with neurons to facilitate synapse plasticity; however, signal transducers
between microglia and neuron remain unknown. Here, using in vitro organotypic hippocampal …

Introduction Tumor lymphocyte infiltration is associated with clinical response to
chemotherapy in estrogen receptor (ER) negative breast cancer. To identify variants in …

Large population-based registry studies have shown that breast cancer prognosis is inherited.
Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human …