Knots form when polymers self-entangle, a process enhanced by compaction with important
implications in biological and artificial systems involving chain confinement. In particular, …

Solid‐state nanopores are a single‐molecule technique that can provide access to biomolecular
information that is otherwise masked by ensemble averaging. A promising application …

We show that a single DNA molecule confined and extended in a nanochannel can be
dynamically compressed by sliding a permeable gasket at a fixed velocity relative to the …

We present an electronic mapping of a bacterial genome using solid-state nanopore
technology. A dual-nanopore architecture and active control logic are used to produce single-…

The preparation and handling of mammalian single-cell genomic DNA is limited by the
complexity bottleneck inherent to performing multi-step, multi-reagent operations in a microfluidic …

NetApp delivers a fast and efficient storage infrastructure for support of CATIA deployments.
New installs or upgrades of CATIA can be quickly and easily deployed on NetApp storage …

Sunday, February 16, 2020 157a that can improve read quality by enabling repeated scanning
at reduced speeds of a molecule that is maintained in a linearized state. A DNA molecule …

Single-molecule techniques can access to biomolecular information that is otherwise
masked by ensemble averaging, and that can lead to new research discoveries or clinically …

Current single cell DNA analysis methods suffer from (i) bias introduced by the need for
molecular amplification and (ii) limited ability to sequence repetitive elements, resulting in (iii) an …

While single-molecule approaches now have a long-history in polymer physics, past methodology
has a key limitation: it is not currently possible to apply well-defined forces to a precise …