HOMELETTE: a unified interface to homology modelling software

P Junk, C Kiel - Bioinformatics, 2022 - academic.oup.com
Homology modelling, the technique of generating models of 3D protein structures based on
experimental structures from related proteins, has become increasingly popular over the …

[PDF][PDF] Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines

T Sevrin, L Strasser, C Ternet, P Junk, M Caffarini… - Iscience, 2023 - cell.com
Cellular utilization of available energy flows to drive a multitude of forms of cellular "work" is
a major biological constraint. Cells steer metabolism to address changing phenotypic states …

Structure-based prediction of Ras-effector binding affinities and design of “branchegetic” interface mutations

P Junk, C Kiel - Structure, 2023 - cell.com
Ras is a central cellular hub protein controlling multiple cell fates. How Ras interacts with a
variety of potential effector proteins is relatively unexplored, with only some key effectors …

Analysis of context-specific KRAS–effector (sub) complexes in Caco-2 cells

C Ternet, P Junk, T Sevrin, S Catozzi… - Life Science …, 2023 - life-science-alliance.org
Ras is a key switch controlling cell behavior. In the GTP-bound form, Ras interacts with numerous
effectors in a mutually exclusive manner, where individual Ras–effectors are likely part …

Linear/Ridge expansions: enhancing linear approximations by ridge functions

C Greif, P Junk, K Urban - Advances in Computational Mathematics, 2022 - Springer
We consider approximations formed by the sum of a linear combination of given functions
enhanced by ridge functions—a Linear/Ridge expansion. For an explicitly or implicitly given …

[HTML][HTML] Disease–Gene Networks of Skin Pigmentation Disorders and Reconstruction of Protein–Protein Interaction Networks

C D'Arcy, O Bass, P Junk, T Sevrin, G Oliviero… - Bioengineering, 2022 - mdpi.com
Melanin, a light and free radical absorbing pigment, is produced in melanocyte cells that are
found in skin, but also in hair follicles, eyes, the inner ear, heart, brain and other organs. …

[HTML][HTML] Engineering of biological pathways: complex Formation and signal transduction

P Junk, C Kiel - Computational Design of Membrane Proteins, 2021 - Springer
The rational in silico design of interface mutations within protein complexes is a synthetic
biology tool that enables—when introduced into biological systems—the artificial rewiring of …

Correction to: Engineering of Biological Pathways: Complex Formation and Signal Transduction

P Junk, C Kiel - Computational Design of Membrane Proteins, 2021 - Springer
In the original version of this book, chapter 4 was published non-open access. It has now
been changed to open access under a CC BY 4.0 license, and the copyright holder has …

Multiple use of Central Amazon floodplains: reconciling ecological conditions, requirements for environmental protection, and socioeconomic needs

JJ Ohly, WJ Junk - Advances in Economic Botany, 1999 - JSTOR
High population growth rates, particularly in so-called Third World countries, create a constant
need to increase food production. However, there are natural and economic limits to a …

Improved correlation of liquid entrainment fraction in horizontal pipes

J Lee, T Skorek, M Junk, PJ Schöffel - Nuclear Engineering and Design, 2022 - Elsevier
New correlations to predict the entrainment fraction in horizontal pipes are proposed based
on the Pan & Hanratty correlation. The Pan & Hanratty correlation cannot properly predict the …