Intracellular aggregation of the human amyloid protein α-synuclein is causally linked to
Parkinson’s disease. While the isolated protein is intrinsically disordered, its native structure in …

The cellular processes underpinning life are orchestrated by proteins and their interactions.
The associated structural and dynamic heterogeneity, despite being key to function, poses a …

The chromo and SET domains are conserved sequence motifs present in chromosomal proteins
that function in epigenetic control of gene expression, presumably by modulating higher …

It has long been axiomatic that a protein’s structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure− function …

Spinal muscular atrophy (SMA) is a common motor neuron disease that results from mutations
in the Survival of Motor Neuron (SMN) gene. The SMN protein plays a crucial role in the …

We introduce a eukaryotic cellular system, the Xenopus laevis oocyte, for in-cell NMR analyses
of biomolecules at high resolution and delineate the experimental reference conditions …

A significant fraction of every proteome is occupied by biologically active proteins that do
not form unique three-dimensional structures. These intrinsically disordered proteins (IDPs) …

“What’s in a name? That which we call a rose By any other name would smell as sweet.”
From “Romeo and Juliet”, William Shakespeare (1594) This article opens a series of …

The essential splicing factors SF1 and U2AF play an important role in the recognition of the
pre-mRNA 3′ splice site during early spliceosome assembly. The structure of the C-terminal …

SUV39H1, a human homologue of the Drosophila position effect variegation modifierSu (var)
3-9 and of the Schizosaccharomyces pombe silencing factorclr4, encodes a novel …