Using an original microfabrication-based technique, we experimentally study situations in
which a virgin surface is presented to a confluent epithelium with no damage made to the cells…

MAMMALIAN cells express many ras-like low molecular mass GTP-binding proteins (rab
proteins) 1–6 that are highly homologous to the Yptl and Sec4 proteins involved in controlling …

The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …

A set of 11 clones encoding putative GTP binding proteins highly homqlogous to the yeast
YP7Y/SEC4 gene products have been isolated from an MDCK cell cDNA library. We localized …

The small GTP-binding protein rab5 was previously localized on early endosomes and on
the cytoplasmic face of the plasma membrane. Using a cell-free assay, we have now tested …

Background Increased mitogen-activated protein kinase (MAPK) signaling, small GTPase
activation, cytoskeletal rearrangements, and the directed targeting of proteases to sites of …

We measure dynamic traction forces exerted by epithelial cells on a substrate. The force
sensor is a high-density array of elastomeric microfabricated pillars that support the cells. …

The Drosophila (fruit fly) model system has been instrumental in our current understanding
of human biology, development, and diseases. Here, we used a high-throughput yeast two-…

Two key events of intracellular transport and membrane trafficking in eukaryotic cells, the
formation of transport vesicles and their specific delivery to target membranes, are controlled by …

When migrating away from a primary tumour, cancer cells interact with and remodel the
extracellular matrix (ECM). Matrix metalloproteinases (MMPs), and in particular the …