Metastasis is an evolutionary process occurring across multiple organs and timescales. Due
to its continuous and dynamic nature, this multifaceted process has been challenging to …

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA …

In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC)
enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung …

Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid
accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and …

Purpose: Although patients with advanced-stage non–small cell lung cancers (NSCLC)
harboring MET exon 14 skipping mutations (METex14) often benefit from MET tyrosine kinase …

Infiltration of macrophages into tissue can promote tumour development. Depending on the
extracellular matrix architecture, macrophages can adopt two migration modes: amoeboid …

Macrophage recruitment is essential for tissue homeostasis but detrimental in most cancers.
Tumor-associated macrophages (TAMs) play a key role in cancer progression. Controlling …

Introduction: Increasing our understanding of drivers of mutagenesis in lung cancer is
critical in our efforts to prevent tumor reoccurrence and resistance. Results: Using the multi-region …

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor
and bi-functional lipid and protein phosphatase. We report that the metabolic regulator …

Relapse of AML patients to FLT3i treatment is the result of a long-term and stepwise process
leading to resistance, whereby residual cancer cells initially survive and subsequently …